Acquisition
Ultrafast, full-field imaging
High-speed cameras record tens of thousands of frames per second over a wide field of view, capturing both large vessels and capillary beds in a single acquisition with no contrast injection.
Laser Doppler Holography
From angiography to clinical endpoints
Retinal blood flow, converted into microvascular function.
Laser Doppler holography records full-field retinal hemodynamics at ultrahigh speed and reconstructs heartbeat-resolved waveforms across the vascular network. The result is not just “imaging” — it is a measurement framework for quantitative, reproducible microvascular endpoints.
Beyond averages. Beat-resolved waveforms per vessel segment.
Beyond single numbers. Families of metrics: flow, resistance, mechanics, rheology.
Built for scale. Reproducible pipelines for multicenter trials & cohorts.
Reference-ready by design. Harmonized hardware + auditable software = comparable metrics across sites.
Manifesto
A measurement framework for microvascular health.
Doppler holography is designed to make microvascular function observable, comparable, and clinically actionable — at scale.
Not an imaging technique looking for applications — a quantitative assay built to turn retinal
dynamics into reproducible endpoints.
The field is moving from images → metrics → clinical endpoints.
Doppler holography enables families of beat-resolved parameters spanning flow, resistance-compliance,
waveform signatures, and rheological/mechanical descriptors — across individual vessels and the full retinal bed.
Non-invasive & repeatable
Full-field & ultrafast
Inspectable metrics
What we optimize for
Reproducibility-first. Comparable measurements across sites.
Endpoint-ready. Metrics designed for trials, not just visualization.
Open by construction. Auditable pipelines for trust & adoption.
What is laser Doppler holography?
Full-field Doppler, encoded in a hologram.
A coherent laser illuminates the retina. An interferometric camera records ultrafast holograms. Digital reconstruction and Doppler demodulation extract flow-sensitive signals, transforming speckle dynamics into stable, quantitative maps of microvascular circulation.
Reconstruction
Digital holography & Doppler
GPU pipelines reconstruct complex-valued holograms and apply Doppler analysis to isolate flow-induced phase dynamics, yielding robust angiographic and velocity-sensitive images.
Endpoints
Families of beat-resolved metrics
Clinical trials won’t be defined by a single number. LDH delivers coherent sets of endpoints: waveform signatures, resistance-compliance surrogates, and rheological/mechanical descriptors at vessel and network scales.
Capabilities
Built for precision, stability, and scale.
Designed for multi-center deployment: stable optics, reproducible software, and transparent metrics. From single-patient exams to cohort-scale infrastructure.
Temporal fidelity
Beat-by-beat hemodynamics
Capture full cardiac cycles per vessel segment, enabling pulse-shape analysis and model-based interpretation that goes far beyond average flow or static images.
Quantitative outputs
Microvascular metrics at scale
Export versioned, traceable endpoints for statistics and AI: flow indices, waveform-derived signatures, resistance-compliance surrogates, and shear-related measures.
Reproducibility
Reference technology for multicenter trials
Harmonized hardware + SOPs + auditable code: reduce site-to-site drift and enable quantitative comparability across continents, demographics, and care pathways.
Clinical workflows
Technician-friendly, scientist-deep
One-click acquisition, automatic QC, structured exports, and a pipeline that stays inspectable from raw holograms to curated metrics.
Applications
A microvascular window to systemic health.
The retina is a uniquely accessible microvascular bed. Beat-resolved flow dynamics can inform ophthalmology, cardiology, neurology, and systemic vascular disease research from a single eye exam.
1 exam
Non-invasive, repeatable acquisition
Families
Endpoints across flow, waveforms, mechanics, rheology
Multi-site
Designed for harmonized deployments & pooled cohorts
Open platform
From raw holograms to curated metrics.
The laser Doppler holography stack is transparent and extensible: hardware guidance, rendering, reconstruction, metric extraction, and cohort-scale management are modular and open. Open source software: Holovibes / HoloDoppler / EyeFlow / DopplerManager / AngioEye
Real-time hologram rendering & visualization
Doppler holography reconstruction pipelines
Velocity & flow estimation from waveforms
Batched image rendering and data analysis
Cohort-scale metrics and biomarkers management
Open by construction. Openness is the scaling mechanism:
shared SOPs and inspectable code enable independent replication, transparent validation,
and trust in quantitative endpoints — the prerequisites for multicenter trials and large cohorts.
Get laser Doppler holography for your clinic or lab
We collaborate with hospitals, universities, and industry partners to deploy, validate, and scale the technology — from pilot studies to multicenter trials and cohort infrastructure.